Tricyclic Antidepressants: Old Drugs-New Applications

tricyclic antidepressants: old drugs-new applications

Tricyclic Antidepressants: Old Drugs-New Applications

With great interest I have read an excellent article " Evaluation of the efficacy of intrathecal injection of amitripty-line and doxepin in spinal anesthesia in comparison with bupivacaine in rats " , published in your respected journal. The authors present and elaborate a very interesting subject of the application of tricyclic antidepressants as a local anesthetic. I totally agree with the au...

Tricyclic antidepressants.

Tricyclic antidepressants.

Correspondence BRiTISH 301 Tricyclic Antidepressants SIR,-I am worried by one sentence in the article on tricyclic antidepressants (13 April, p. 102): "Jaundice, which is very uncommon , is of the cholestatic type similar to that found in chlorpromazine." This is misleading. Jaundice is one of the more frequent side-effects reported from imipramine and imitrip-tyline, the most widely used membe...

Pharmacokinetics of Tricyclic Antidepressants

This review, together with Part 1 (Gun. Chem. 26: 5-17, 1980), summarizes progress in measurement of tricyclic antidepressants in biological fluids and the application of the methodology to Clinical practice. For many of the older drugs and for all of the new-generation antidepressants, further studies are required to delineate the precise relationship between plasma concentration and clinical ...